Biocompatible Delivery Systems Based on κ-Carrageenan and Nonionic Surfactants

Abstract
Biocompatible transport binary and ternary delivery systems of bioactive substances based on biopolymer (kappa)-carrageenan and nonionic surfactants in aqueous media have been created. Their liquid crystal properties were studied. The temperature regions of the lyomesophase formation were found. The in vitro process of releasing riboflavin from the synthesized lyotropic systems was studied using a simple diffusion model. Viscoelastic properties were studied. The analysis of flow curves in the framework of various rheological models was carried out. The basic patterns on the influence of the supramolecular organization type of system (lamellar and hexagonal) and rheological characteristics on drug release were revealed.

Keywords: yotropic liquid crystals, biocompatible systems, κ-carrageenan, rheology, flow model, release, riboflavin