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O. V. Alekseeva¹, N. A. Bagrovskaya¹, O. G. Sitnikova², S. B. Nazarov²

Author affiliations
¹G. A. Krestov Institute of Solution Chemistry of the Russian Academy of Sciences
Akademicheskaya str. 1, 153045 Ivanovo, Russia. 
E-mail: ova@isc-ras.ru
²Ivanovo Research Institute of Maternity and Childhood named after V. N. Gorodkov,
Pobedy str., 20, 153002 Ivanovo, Russia

Abstract
Sorption and structural characteristics of hydroxyapatite: the specific surface area and pore volume were determined. It is shown that the studied powder hydroxyapatite can be attributed to the mesoporous solid with highly developed surface area. Immobilisation of hydroxyapatite particles in polystyrene matrix was carried out by mechanical dispersion method. Interaction of the polymer matrix with filler microparticles was studied by IR spectroscopy. The main indicators of chemiluminescence and spectrophotometry characterising the process of lipid peroxidation in blood serum were determined in vitro. It was established that the polymer composites, depending on the concentration of the filler particles have ability to inhibit processes of serum lipids’ free radical oxidation.

Keywords: polystyrene, hydroxyapatite, immobilisation, antioxidant activity, lipid, chemiluminescense