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Liquid Crystals and their Application Russian Journal Zhidkie kristally i ikh prakticheskoe ispol'zovanie Жидкие кристаллы и их практическое использование |
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Zhidk. krist. ikh prakt. ispol'z. = Liq. Cryst. and their Appl., 2010, 3, 57—63. |
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Prediction of Biological Activity of Benzylideneaniline Structural Analogues
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T. G. Volkova1, K. V. Balakin2, Ya. A. Ivanenkov2, M. V. Klyuev1
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Author affiliations 1Ivanovo State University, Department of Organic and Biological Chemistry,
153025 Ivanovo, Ermak st., 39
2Institute of Physiologically Active Substances, Russian Academy of Sciences,
142432, Chernogolovka, Moscow Region, North Passage, 1
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Abstract The classification model, which allows predicting the effectiveness of non-covalent complexes formation between low molecular organic compounds (derivatives of benzylideneaniline) and protein macromolecules is proposed. The type of the biological activity depends on a number of carbon atoms in the side alkyl chain. The affinity of the benzylideneaniline derivatives is determined by their active conformation.
Keywords: biological activity, benzylideneaniline derivatives, structure – property correlation
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