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Liquid Crystals and their Application
Russian Journal

Zhidkie kristally i ikh prakticheskoe ispol'zovanie

Жидкие кристаллы и их практическое использование

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Rus Eng


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Zhidk. krist. ikh prakt. ispol'z. = Liq. Cryst. and their Appl., 2018, 18 (3), 6—13.
DOI: 10.18083/LCAppl.2018.3.6

Lyotropic Mesophases Based an Chitosane Biopolymer, Acetic Acid and Non-Ionic Surfactants, as Delivery Systems of Bioactive Substances

N. M. Selivanova1, A. T. Gubaidullin2, Yu. G. Galyametdinov1

Author affiliations
1Kazan National Research Technological University,
68 Karl Marx St., Kazan, 420015, Russia
2Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of RAS,
8 Arbuzov St., Kazan, 420088, Russia

New self-organizing systems based on the chitosan biopolymer, acetic acid and non-ionic surfactants have been synthesized. Their liquid crystalline properties were studied by polarizing optical microscopy. Phase diagrams of the systems were constructed. The concentration and temperature ranges of lyomesophases were established. The rheological properties of mesophases with different supramolecular organization were estimated. In vitro release of rhodamine 6G from the synthesized systems was investigated using the Franz diffusion cell as a transmembrane model of passive diffusion. Analysis of mass transfer kinetics has shown that the proposed lyotropic systems have a great potential as delivery systems for bioactive substances.

Keywords: lyotropic liquid crystals, chitosan, acetic acid, delivery systems, release, rhodamine

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