Effects of Specific and Non-Specific Interactions on Solvation Enthalpy Parameters of Amino Acids in Aqueous Organic Solvents

Abstract
The enthalpy coefficients of pair-wise interactions h_xy for the amino acid – co-solvent pair has been evaluated at infinitive dilution concentration using the McMillan-Mayer theory in the ternary aqueous systems. It was showed that the enthalpy coefficients of pair-wise intermolecular interaction of amino acids with organic co-solvents depend on the properties of these solvents and can be quantitatively expressed in the form of the multi-parameter equations (by the LSER principle). The estimation of specific (predominantly electron donor type) and non-specific solvation effects in studied the systems was carried out.

Keywords: amino acids, aqueous organic solutions, enthalpy, multi-parameter equations