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R. F. Bakeeva, O. E. Vakhitova, T. S. Gorbunova, V. F. Sopin

Author affiliations
Kazan National Research Technological University,
68 Karl Marx St., Kazan, 420015, Russia
E-mail: bakeeva@kstu.ru

Abstract
Micellar systems of surfactants can be used for solubilization improvement of poorly water-soluble organic compounds, including medicinal substances and their precursors. Results of the solubilization study of the medicinal substance precursor 5,7-dichloro-4,6-dinitrobenzofuroksan are given. Speсtrophotometric and tenziometric methods were used for the analysis of the micellar systems of nonionic surfactants such as 4-(1,1,3,3-tetrametylbutylphenoxypolyethoxyethanol) (Tr X-100), polyoxyethylene (10) cetyl ether (Brij 56), cationic surfactant – cetyltrimethylammonium bromide (CTAB), anionic surfactant – sodium dodecylsulphate (SDS). Solubilization ability of surfactant was considered in the terms of molar solubilization ratio (R_m,s), the micelle–water partition coefficient (К_м) and the free energy of solubilization (ΔG_s⁰). Solubilization effectiveness of surfactant micelles for 5,7-dichloro-4,6-dinitrobenzophuroxan varies among the following sequence: SDS < CTAB < Tr X-100 < Brij56. The negative values of the free solubilization energy testify to its spontaneous character. The fulfilled comparative study will help to choose targetly the suitable environment for organic synthesis with the use of 5,7-dichloro-4,6-dinitrobenzofuroxan, and also for analytical definitions. Low values of CMC of nonionic surfactants, their low toxicity and large solubilization capacity allow to recommend these surfactants for creation of nanocontainers at designing the delivery systems of medicinal substances to the target.

Keywords: supramolecular systems, micelles, solubilization, 5,7-dichloro-4,6-dinitrobenzofuroxan, molar solubilization ratio, micelle–water partition coefficient, ionic, nonionic surfactant