Dear authors and readers!
We are pleased to inform that the journal Liquid Crystals and their Application is included in Web of Science (Emerging Sources Citation Index) and Scopus databases.
Zhidk. krist. ikh prakt. ispol'z. = Liq. Cryst. and their Appl., 2015, 15 (3), 134—142. DOI: 10.18083/LCAppl.2015.3.134
Solubilization of 5,7-Dichloro-4,6-Dinitrobenzofuroxsan in Surfactants Micelles
R. F. Bakeeva, O. E. Vakhitova, T. S. Gorbunova, V. F. Sopin
Author affiliations Kazan National Research Technological University,
68 Karl Marx St., Kazan, 420015, Russia E-mail: email@example.com
Abstract Micellar systems of surfactants can be used for solubilization improvement of poorly water-soluble organic compounds, including medicinal substances and their precursors. Results of the solubilization study of the medicinal substance precursor 5,7-dichloro-4,6-dinitrobenzofuroksan are given. Speсtrophotometric and tenziometric methods were used for the analysis of the micellar systems of nonionic surfactants such as 4-(1,1,3,3-tetrametylbutylphenoxypolyethoxyethanol) (Tr X-100), polyoxyethylene (10) cetyl ether (Brij 56), cationic surfactant – cetyltrimethylammonium bromide (CTAB), anionic surfactant – sodium dodecylsulphate (SDS). Solubilization ability of surfactant was considered in the terms of molar solubilization ratio (Rm,s), the micelle–water partition coefficient (Км) and the free energy of solubilization (ΔGs0). Solubilization effectiveness of surfactant micelles for 5,7-dichloro-4,6-dinitrobenzophuroxan varies among the following sequence: SDS < CTAB < Tr X-100 < Brij56. The negative values of the free solubilization energy testify to its spontaneous character. The fulfilled comparative study will help to choose targetly the suitable environment for organic synthesis with the use of 5,7-dichloro-4,6-dinitrobenzofuroxan, and also for analytical definitions. Low values of CMC of nonionic surfactants, their low toxicity and large solubilization capacity allow to recommend these surfactants for creation of nanocontainers at designing the delivery systems of medicinal substances to the target.